Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: A systematic review

HR Chinnery; R Rajan; H Jiao; M Wu; AC Zhang; MEH De Silva; E Makrai; MA Stepp; N Di Girolamo; LE Downie

Journal article

Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: A systematic review

HR Chinnery, R Rajan, H Jiao, M Wu, AC Zhang, MEH De Silva, E Makrai, MA Stepp, N Di Girolamo, LE Downie

British Journal of Ophthalmology | BMJ PUBLISHING GROUP | Published : 2022

DOI: 10.1136/bjophthalmol-2020-318156

Abstract

Background/aims This systematic review critically evaluated peer-reviewed publications describing morphological features consistent with, or using terms related to, a 'neuroma' or 'microneuroma' in the human cornea using laser-scanning in vivo confocal microscopy (IVCM). Methods The review was prospectively registered on PROSPERO (CRD42020160038). Comprehensive literature searches were performed in Ovid MEDLINE, Ovid Embase and the Cochrane Library in November 2019. The review included primary research studies and reviews that described laser-scanning IVCM for examining human corneal nerves. Papers had to include at least one of a pre-specified set of keyword stems, broadly related to neurom..

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University of Melbourne Researchers

Holly Chinnery Author

Alexis Ceecee Britten-Jones Author

Laura Downie Author

Mengliang Wu Author

Related Projects (1)

DEEPENING OUR UNDERSTANDING OF OCULAR SURFACE NEUROIMMUNOLOGY

It is becoming clear that the interaction between corneal nerves and immune cells underpin many inflammatory conditions of the ocular surfac..

Grants

Awarded by National Eye Institute

Funding Acknowledgements

National Health and Medical Research Council of Australia APP1126540 (HRC); Rebecca L Cooper Medical Foundation (LED); NIH/NEI EY08512 (MAS); National Health and Medical Research Council of Australia, APP1101078 and APP1156944 (ND). The funding organisations had no role in the design or conduct of this work.